NGS-Based Custom Reference Databases Expand the Reach of Proteomics Beyond Model Systems | GenomeWeb

This story originally ran on May 10.

Though in proteomics the proteome is, of course, the ultimate concern, mass spec-based approaches rely on DNA reference databases for matching experimental spectra and peptide sequences to their corresponding proteins.

This isn't a problem so long as researchers confine their studies to organisms with fully sequenced, well-annotated genomes. It can become an issue, however, for scientists working on less commonly investigated, non-model systems.

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