Quark Begins Enrollment in Glaucoma Drug Trial | GenomeWeb

NEW YORK (GenomeWeb) – Quark Pharmaceuticals announced this week that it has dosed the first patient in a Phase IIa study of QPI-1007, its siRNA-based treatment for glaucoma.

QPI-1007 is composed of siRNAs designed to inhibit the pro-apoptotic gene caspase 2 and was first tested clinically as a treatment for non-arteritic anterior ischemic optic neuropathy (NAION), a rare disorder characterized by the death of retinal ganglion cells — the same cause of glaucoma-related blindness.

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